QSMetric Potential Indications – Haemochromatosis
Discover a potential indication of QSMetric™ technology.
Primary haemochromatosis, which is genetic in origin, is a dysregulation of the absorption and recycling of iron in the body. These dysregulations lead to the accumulation of iron in various organs. Secondary haemochromatosis is associated with regular blood transfusions. Disruption or rupture of the blood-brain barrier can also lead to changes in susceptibility.
Iron accumulations in the central nervous system are mainly located in the pituitary gland and choroid plexus. Cerebral accumulations often follow systemic manifestations. Using MRI, the changes in susceptibility induced by iron accumulations can be quantified and used to characterise brain damage.
- McDermott JH, Walsh CH. “Hypogonadism in hereditary hemochromatosis” The Journal of clinical endocrinology and metabolism, 2005
- Seth et al, Quantifying “Brain Iron in Hereditary Hemochromatosis Using R2* and Susceptibility Mapping” Am J Neuroradiol. 2022
